Turkeys.

2018-19 Rapid Ag: MnPoPPA: Informing strategies for autogenous vaccine development in poultry

May 15, 2017

Principal Leader

Timothy Johnson

Department

Veterinary and Biomedical Sciences

Funding Awarded

  • 2018 Fiscal Year: $102,026 
  • 2019 Fiscal Year: $94,026

The Problem

In 2017, the Veterinary Feed Directive (VFD) issued by the U.S. Food and Drug Administration (FDA) will limit the use of medically important antibiotics in animal agriculture and will require veterinarian prescriptions for other forms of antibiotic use in production animals. More information is needed to fully understand the implications of these changes and to develop alternative forms of treatments that will lesson the impact of this change in animal production systems. 

Background

This is a landmark year (2017) in the fight against antibiotic-resistant bacterial pathogens in the United States. Starting this year, the VFD issued by the FDA will limit the use of medically important antibiotics in animal agriculture, and it will require veterinarian prescriptions for other forms of antibiotic use in production animals (1). While this is an important step in reducing our overall use of antibiotics as a society, we do not fully understand the implications of these changes. How will such changes impact the occurrence of bacterial disease in production animals? How will this, in turn, impact the therapeutic use of antibiotics as a whole to treat such infections? An implied expectation of the FDA’s VFD is that we successfully identify and effectively implement alternatives to antibiotics that will aid in the prevention of disease and will sustain animal production.

Goals and Objectives

This project addresses urgent needs by poultry producers in Minnesota to better identify suitable autogenous vaccine strains, and more effectively rotate between vaccine strains based upon changes in pathogen populations. The first goal of this project is to develop a tool called Minnesota Poultry Pathogen Population Analysis (MnPoPPA) for the assessment of pathogen ecology by poultry producers in Minnesota. The second goal of this project is to design modeling approaches that can be used to predict pathogen population shifts following implementation of a vaccine within a poultry producing system. These goals will be accomplished with the following objectives:

  1. Build MnPoPPA for rapid analysis of pathogen ecology within a poultry system
  2. Populate MnPoPPA with relevant bacterial pathogens for Minnesota poultry producers
  3. Design models that predict pathogen population shifts following autogenous vaccine implementation

References

1. FDA. 2015. Veterinary Feed Directive.